Gene name:
Melk (Kiaa0175;Pk38) ;
Protein name:
Maternal embryonic leucine zipper kinase ;
Alternative:
2.7.10.2;Tyrosine-protein kinase MELK ) ;Protein kinase PK38 (mPK38) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer. Interacts with ZNF622 and PPP1R8.
Function:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Protein Attributes:
50:
MKDYDELLKY | YELYETIGTG | GFAKVKLACH | VLTGEMVAIK | IMDKNALGSD |
100:
LPRVKTEIDA | LKSLRHQHIC | QLYHVLETKN | KIFMVLEYCP | GGELFDYIIS |
150:
QDRLSEEETR | VVFRQILSAV | AYVHSQGYAH | RDLKPENLLF | DENHKLKLID |
200:
FGLCAKPKGN | KDYHLQTCCG | SLAYAAPELI | QGKSYLGSEA | DVWSMGILLY |
250:
VLMCGFLPFD | DDNVMALYKK | IMRGKYEVPK | WLSPSSILLL | QQMLQVDPKK |
300:
RISMRNLLNH | PWVMQDYSCP | VEWQSKTPLT | HLDEDCVTEL | SVHHRSSRQT |
350:
MEDLISSWQY | DHLTATYLLL | LAKKARGKPA | RLQLLSFSCG | TASTTPKSKN |
400:
LSLEDMSTSD | DNCVAGLIDY | ELCEDKLLAP | KTPQVTKHLA | ESNHAASKSP |
450:
APGVRRAVAN | KLMDKENVCT | PKSSVKNEEQ | FVFSEPKIPV | SKNQYKREIP |
500:
ASPTRFPTPA | KARAQCLREA | PVRTPGNSAG | ADTLTTGVIS | PERRCRSMDV |
550:
DLNQAHMEDT | PKKKGTNVFG | SLERGLDKVL | TALTRNKKKG | SARDGPRKRK |
600:
LHYNVTTTRL | VNPDQLLSEI | MAILPKKNVD | FVQKGYTLKC | QTQSDFGKVT |
643:
MQFELEVCQL | QRPDVVGIRR | QRLKGDAWVY | KRLVEDILSG | CKM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Maternal embryonic leucine zipper kinase
ELISA Kit for Mouse Maternal embryonic leucine zipper kinase
CLIA Kit for Mouse Maternal embryonic leucine zipper kinase
CLIA Kit for Mouse Maternal embryonic leucine zipper kinase
Polyclonal Antibody for Mouse Maternal embryonic leucine zipper kinase
Polyclonal Antibody for Mouse Maternal embryonic leucine zipper kinase
Monoclonal Antibody for Mouse Maternal embryonic leucine zipper kinase
Monoclonal Antibody for Mouse Maternal embryonic leucine zipper kinase
Protein for Mouse Maternal embryonic leucine zipper kinase
Protein for Mouse Maternal embryonic leucine zipper kinase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue :
Keratinocyte .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain :
C57BL/6 X DBA/2 .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
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Embryo .
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Spinal cord .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Embryonic tail .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF MAP3K5;MUTAGENESIS OF LYS-40
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]