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Index > Protein center > Melk(Gene name) > Mouse
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  • Melk (Gene name),
  • Maternal embryonic leucine zipper kinase (Protein name ),  MELK_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Melk(Kiaa0175;Pk38);
    Protein name:
    Maternal embryonic leucine zipper kinase;
    Alternative:
    2.7.10.2;Tyrosine-protein kinase MELK);Protein kinase PK38(mPK38);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with ZNF622 and PPP1R8.
    Function:
    Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
    Subcellular Location:
    Cell membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    643
    Sequence:
    50:
    MKDYDELLKY | YELYETIGTG | GFAKVKLACH | VLTGEMVAIK | IMDKNALGSD | 
    100:
    LPRVKTEIDA | LKSLRHQHIC | QLYHVLETKN | KIFMVLEYCP | GGELFDYIIS | 
    150:
    QDRLSEEETR | VVFRQILSAV | AYVHSQGYAH | RDLKPENLLF | DENHKLKLID | 
    200:
    FGLCAKPKGN | KDYHLQTCCG | SLAYAAPELI | QGKSYLGSEA | DVWSMGILLY | 
    250:
    VLMCGFLPFD | DDNVMALYKK | IMRGKYEVPK | WLSPSSILLL | QQMLQVDPKK | 
    300:
    RISMRNLLNH | PWVMQDYSCP | VEWQSKTPLT | HLDEDCVTEL | SVHHRSSRQT | 
    350:
    MEDLISSWQY | DHLTATYLLL | LAKKARGKPA | RLQLLSFSCG | TASTTPKSKN | 
    400:
    LSLEDMSTSD | DNCVAGLIDY | ELCEDKLLAP | KTPQVTKHLA | ESNHAASKSP | 
    450:
    APGVRRAVAN | KLMDKENVCT | PKSSVKNEEQ | FVFSEPKIPV | SKNQYKREIP | 
    500:
    ASPTRFPTPA | KARAQCLREA | PVRTPGNSAG | ADTLTTGVIS | PERRCRSMDV | 
    550:
    DLNQAHMEDT | PKKKGTNVFG | SLERGLDKVL | TALTRNKKKG | SARDGPRKRK | 
    600:
    LHYNVTTTRL | VNPDQLLSEI | MAILPKKNVD | FVQKGYTLKC | QTQSDFGKVT | 
    643:
    MQFELEVCQL | QRPDVVGIRR | QRLKGDAWVY | KRLVEDILSG | CKM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Maternal embryonic leucine zipper kinase
    Cat.:
    E15058h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Maternal embryonic leucine zipper kinase
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Maternal embryonic leucine zipper kinase
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Maternal embryonic leucine zipper kinase
    Cat.:
    U15058h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Maternal embryonic leucine zipper kinase
    Polyclonal Antibody for Mouse Maternal embryonic leucine zipper kinase
    Monoclonal Antibody for Mouse Maternal embryonic leucine zipper kinase
    Monoclonal Antibody for Mouse Maternal embryonic leucine zipper kinase
    Protein for Mouse Maternal embryonic leucine zipper kinase
    Protein for Mouse Maternal embryonic leucine zipper kinase

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells."
      Gil M. , Yang Y. , Lee Y. , Choi I. , Ha H.
      Gene195:295-301(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Keratinocyte.
    2. 2.
      "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo."
      Heyer B.S. , Warsowe J. , Solter D. , Knowles B.B. , Ackerman S.L.
      Mol. Reprod. Dev.47:148-156(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      strain: C57BL/6 X DBA/2.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Spinal cord.
    4. 4.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Embryonic tail.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      "Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation."
      Nakano I. , Paucar A.A. , Bajpai R. , Dougherty J.D. , Zewail A. , Kelly T.K. , Kim K.J. , Ou J. , Groszer M. , Imura T. , Freije W.A. , Nelson S.F. , Sofroniew M.V. , Wu H. , Liu X. , Terskikh A.V. , Geschwind D.H. , Kornblum H.I.
      J. Cell Biol.170:413-427(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    8. 8.
      "Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation."
      Jung H. , Seong H.A. , Ha H.
      J. Biol. Chem.283:34541-34553(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MAP3K5;MUTAGENESIS OF LYS-40
    9. 9.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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